Hyaluronic acid (HA) fillers are sterile gels containing non-animal stabilized hyaluronic acid, used for correcting facial lines, wrinkles, folds, enhancing lips, and shaping facial contours through injection into the skin. There are instances where these fillers need to be dissolved, such as when the desired outcome is not achieved, or when there is a risk of vascular occlusion or tissue necrosis, which may compromise healthy tissue. Hyaluronidase, an enzyme, facilitates the breakdown of hyaluronic acid fillers; however, it can also break down naturally occurring hyaluronic acid in the body, leading to unpredictable results. While the body may reproduce natural hyaluronic acid in many cases, there may be a loss of volume and skin laxity, potentially affecting the aesthetic outcome.

It's important to note that severe complications may arise in individuals with allergies to bees/wasps or ingredients in Hyaluronidase. Possible side effects include signs of allergic reactions like hives, difficulty breathing, and swelling of the face, lips, tongue, or throat. Additionally, injection-related reactions such as pain, itching, redness, bruising, or swelling at the injection site may occur, typically resolving within a few days.

After the procedure, patients are required to remain at the clinic for thirty minutes for observation by the practitioner. Follow-up appointments, typically scheduled two weeks post-treatment, may be necessary to assess the need for further hyaluronidase administration.